Dopamine is a neurotransmitter and a hormone that plays a significant role in our mood, motivation, and pleasure. Under normal circumstances, dopamine production is managed effectively by the body’s nervous system. However, low levels of dopamine can greatly impact one’s quality of life and has often been linked to depression, anxiety, and other mental health conditions. While there are several ways to increase dopamine naturally, some people find it helpful to take dopamine supplements to boost their mood.
With several dopamine supplements on the market, it can be critical to choose the right one for your needs. Some of the most common ones include L-tyrosine, which is often used to enhance cognitive performance, reduce stress, and improve mood. Phenylalanine is used to treat depression and chronic pain. While Mucuna pruriens is commonly used to improve mood, reduce stress, and enhance cognitive function.
Each type has its benefits and drawbacks, therefore we have gathered a list of the best dopamine supplements to boost your mood, reduce stress, or improve cognitive performance. As we review each one, you will have the ability to make a well-informed decision so you can reap from its benefits.
What is Dopamine Deficiency?
Dopamine is a chemical messenger that communicates messages between nerve cells in or between your brain and the rest of your body. It plays an important role in various body functions such as the regulation of cognition, memory, attention, learning, sleep, movement, and motivation. Therefore, the right balance of dopamine is essential for both physical and mental well-being.
Dopamine deficiency means having there may have been a drop in the amount of dopamine the body makes or an issue with dopamine receptors in the brain. There are various lifestyle factors and medical conditions that can cause dopamine levels to plummet. Some of these include sleep deprivation, stress, obesity, saturated fats, drug abuse, among others.
Health Conditions Linked to Dopamine Deficiency

There are a number of physical and mental health conditions that can lead to low dopamine levels, however scientists are still learning its role in its cause. Some of these health conditions include:
- Major Depressive Disorder (Clinical Depression)
This is the most severe mental and behavioral disorders characterized by depressive moods and a lack of interest in activities that were once enjoyed, also known as anhedonia. This loss of interest is due to a disruption in the mind’s reward process. The usual excitement, motivation, and decision-making stages involved in the reward system are greatly affected due to dysfunctions in the dopamine system.
In a review by Belujon et al. (2017), dopamine plays a critical role in the body and confirms its association with major depressive disorder.
- Parkinson’s Disease
This is a degenerative disorder of the central nervous system. Common symptoms include tremors, muscle stiffness, delayed movement, and problems with balance and coordination. While Parkinson’s disease is the result of a number of factors, it is mainly due to a loss of dopamine-producing cells.
- Schizophrenia
This disorder is a severe mental health condition that can affect a person’s ability to think, act, or express themselves. With a distorted interpretation of reality, its common symptoms include hallucinations, delusions, and abnormal physical gaits that are attributed to an imbalance of dopamine in the body.
Dopamine is said to play a role in the cause of the disorder, including other neurotransmitters such as GABA and glutamate. A research by Murray et al. (2008) suggests that developmental risk factors which increase the risk of Schizophrenia is due to dopamine dysregulation.
- Attention-Deficit/Hyperactivity Disorder (ADHD)
This neurodevelopmental disorder is when an individual has difficulty focusing, paying attention, or controlling impulsive and hyperactive behavior. While there are no exact causes for ADHD, research has shown that it may be associated with changes in dopamine activity due to genetic mutations.
- Obsessive-Compulsive Disorder (OCD)
This anxiety disorder is believed to be dysregulated by dopamine, along with serotonin and glutamate. Common symptoms of OCD include developing obsessions (intrusive thoughts or images that trigger emotional distress) and compulsions (behaviors someone engages in to decrease obsessions). It may also involve damped dopamine-receptor activity and increased dopamine activity in some areas of the brain.
- Drug Abuse
Drug abuse may greatly affect dopamine levels in the body. In a 2017 review, it was found that the repeated use of stimulants could alter dopamine cell activation and signaling. Those who misused drugs have also had a significant decrease in dopamine D2 receptors and dopamine release, making it more difficult for a person to have positive effects from dopamine.
- Diet
Having a diet composed of saturated fats and a lack of protein can significantly affect dopamine levels. In a 2018 study, researchers hypothesized that high levels of saturated fat may increase inflammation, which contributes to changes in the dopamine system. A lack of protein in a person’s diet may also signify that they do not have enough l-tyrosine, an amino acid that creates dopamine in the body.
- Obesity or Binge-Eating Disorder (BED)
BED involves recurrent binging on large amounts of food very quickly and is often accompanied by feeling a loss of control, shame, distress or guilt. In a 2019 review, dopamine dysregulation has been suggested as a possible biological cause for this condition as it involves impulse control and the reward centers of the brain.
Additionally, a 2010 study by Johnson and Kenny showed conclusive evidence that being overweight lowers the activity of dopamine receptors in humans. This could change neural reward pathways that are activated by eating. In turn, some experts believe it shares a similar role in addiction.
Signs of Dopamine Deficiency

Low levels of dopamine can have a variety of physical, cognitive, and emotional effects. Different conditions vary in symptoms depending on the region of the brain where dopamine activity is lacking. Common symptoms of dopamine deficiency include:
- Chronic back pain
- Constipation
- Stiff or achy muscles
- Weight fluctuation
- Fatigue or lack of energy
- Sleep disorders
- Difficulty focusing or paying attention
- Mood swings
- Reduced sex drive
- Hallucinations and delusions
- Dysphagia or difficulty swallowing
- Brain fog
- Diminished balance and coordination
- Slow movement or speech
- Impairment of fine motor skills (ex: holding a pencil or threading a needle)
If you experience several of these symptoms, you may have dopamine deficiency. In this case, be sure to consult with your healthcare provider so you can be properly diagnosed and treated.
Best Dopamine Supplements to Boost Your Mood
If you’re struggling with your mood, focus, and motivation, then dopamine supplements may be worth considering. While there are several ways to increase your dopamine levels, we have rounded up the best dopamine supplements on Amazon to help you manage your symptoms for that extra boost! Regulating your mood, motivation, and pleasure can surely make a difference for a better and more positive life.












TWINLEAF Dopamine Brain Food Natural Supplement
- Brain Health Support for Women & Men - TWINLEAF supplement is designed to support brain health with ingredients like L-Tyrosine, known for its role in neurotransmitter synthesis, and Mucuna Pruriens, a natural botanical. It's a comprehensive formula catering to the overall wellbeing of both men and women.
- Supporting Mental Well-being - Our supplement is crafted to support your mental well-being. While dopamine is a key neurotransmitter in the brain, our formula focuses on providing nutritional support through natural ingredients, helping you stay engaged in your daily activities.
- Focus, Memory, Clarity, Energy - Apart from Mucuna Pruriens & L-Tyrosine, our formula contains vitamin B-12, phosphatidylserine, green tea extract, Panax ginseng, and ginkgo Biloba - ingredients famous for replenishing energy, promoting better focus and memory, and supporting brain support & upbeat mood.
Do you need that extra mood boost and productivity for your day? If so, then look no further! TWINLEAF Dopamine Brain Food Natural Supplement may be exactly what you need.
Pros | Cons |
Contains L-Tyrosine and Mucuna Pruirens to boost dopamine production. Improves mental drive, motivation, focus, memory, clarity, and energy. Contains a blend of natural ingredients including vitamin B-12, phosphatidylserine, green tea extract, Panax ginseng, and ginkgo Biloba. | May take some time to see noticeable results. Effectiveness may vary per person. May cause minor side effects such as headaches or nausea. |
This supplement is a great choice to improve their mood and productivity. It contains natural ingredients such as L-Tyrosine and Mucuna Pruirens to boost dopamine production, which is crucial for learning, general productivity, and mental drive. This supplement also incorporates other beneficial components including vitamin B-12, phosphatidylserine, green tea extract, Panax ginseng, and ginkgo Biloba, which can help to replenish energy, promote better focus and memory, and support brain function and an upbeat mood.
However, it may take time to see results after taking TWINLEAF Dopamine Brain Food Natural Supplement. While it is generally considered safe and effective for your mental health and well-being, it may not work on everyone. Additionally, some users may experience minor side effects such as headaches or nausea.
Dr. Maxwell Serotonin and Dopamine Supplements
- Taking a serotonin and dopamine support supplement is better than taking a supplement to support only dopamine or only serotonin. This is because Dopamine (motivation and reward) and Serotonin (learning and mood) work in a delicate balance. Unlike leading alternatives, Dr Maxwell’s formula contains precursors of both dopamine and serotonin so it helps maintain normal neurotransmitter levels*
- Mood support and relaxation: Dr Maxwell’s formula provides Magnesium and Vitamin D3 to support overall well-being, mood and relaxation*
- Focus and brain support: our formula contains Ashwagandha, L-theanine and Taurine to support daily cognitive function and mental tasks*
Everyone experiences a slow and sluggish day! And if you’re looking to avoid that, then Dr. Maxwell’s Serotonin and Dopamine Supplements may be the right choice for you. This supplement offers both dopamine and serotonin, as well as nutrients for mood support and relaxation, and focus and brain support.
Pros | Cons |
Precursors of both dopamine and serotonin for maintaining normal neurotransmitter levels. Nutrients for mood support and relaxation. Features ingredients like Ashwagandha, L-theanine, and taurine for focus and brain support. | Effectiveness may vary per person. Some users have reported side effects such as anxiety and muscle spasms. Contains magnesium, which may cause digestive issues for some users. |
Dr. Maxwell’s Serotonin and Dopamine Supplements has a formula including precursors of both dopamine and serotonin, which work together to maintain normal neurotransmitter levels. It incorporates nutrients such as magnesium and vitamin D3 for mood support and relaxation, as well as ashwagandha, L-theanine, and taurine for focus and brain support.
While this supplement may not work for everyone, it has received positive reviews from many users who have experienced improved mood and cognitive function. However, some users have reported side effects such as anxiety and muscle spasms, therefore it’s important to read the label before taking this supplement or speak to a healthcare provider. Additionally, this supplement contains magnesium, which may cause digestive issues in some users.
NOW Supplements, DOPA Mucuna
- STANDARDIZED MUCUNA EXTRACT: Traditional Ayurvedic herb used for health and wellness*
- NATURALLY OCCURRING 15% L-DOPA: Supports dopamine production, which promotes enjoyment and interest in life*
- CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Non-GMO, Vegan, Nut Free, Made without Gluten, Dairy Free, Egg Free, Halal
Are you lacking motivation in life? If you are, then worry no more! With NOW Supplements, DOPA Mucuna, you can naturally boost your dopamine levels so you can get the excitement you’ve been yearning for on a daily basis.
Pros | Cons |
Traditional Ayurvedic herb used for health and wellness. Supports dopamine production, which promotes enjoyment and interest in life. Soy Free, Non-GMO, Vegan, Nut Free, Made without Gluten, Dairy Free, Egg Free, Halal. | Effectiveness may vary per person. Some users reported mild side effects such as nausea and headaches. May take time to see results. |
NOW Supplements, DOPA Mucuna is a natural supplement that promotes enjoyment and interest in life. The standardized Mucuna extract is a traditional Ayurvedic herb that has been used for health and wellness for centuries. This product contains naturally occurring 15% L-DOPA, which supports dopamine production, promotes pleasure, motivation, and attention. It is also soy-free, non-GMO, vegan, nut-free, made without gluten, dairy-free, egg-free, and Halal.
While NOW Supplements, DOPA Mucuna may not work for everyone, it has become a top option for several people looking to naturally boost their dopamine levels. Mild side effects such as nausea and headaches were reported by some users, although they are uncommon. Additionally, it may take time to see its full effects.
NatureBell Triple Strength Mucuna Pruriens Capsules
- Triple Strength Mucuna Pruriens Extract Plus Ashwagandha (Made with Mucuna Dopa) 1500mg, 240 Capsules, 2 in 1 Formula, Non-GMO and Made in USA.
- Supports Relaxation and Recovery, Naturally Supports Mood and Benefits Nervous System.
- Natural Performance Enhancer and Booster for Both Men and Women.
NatureBell Triple Strength Mucuna Pruriens Capsules is a supplement worth trying if you need additional support to boost your mood and nervous system.
Pros | Cons |
Contains Mucuna Dopa and Ashwagandha to boost your mood and support relaxation and recovery. Generous supply of 240 capsules per bottle that can last for months. Non-GMO, gluten-free, and free from artificial colors, flavors, and soy. | Its effectiveness may vary per person. Some users have reported feeling anxious or experienced stimulant effects. May take time to see its full effects. |
NatureBell Triple Strength Mucuna Pruriens Capsules can be a great addition to your wellness routine if you’re looking for a natural way to enhance your mood and support your nervous system. With its potent seed extract and non-GMO, gluten-free formula, it’s a supplement that can work for many people. It offers a generous supply of 240 capsules per bottle, which ensures an extended duration of use.
However, it’s important to keep in mind its effectiveness may vary and it may take time to see its full effects. Some users have also reported feeling anxious or experienced stimulant effects after taking the recommended doses.
Lifted Naturals Probiotics
- TARGETED "FEEL GOOD" STRAINS: Unleash the transformative power of our meticulously selected bacterial strains crafted to uplift your mood. Engineered with precision for enhanced mood support, these strains become your daily companions on the journey to a more joyful and positive you with our probiotic and prebiotic for women & men.
- HIGH POTENCY FOR MOOD & DIGESTION: Elevate your overall well-being with a robust 30 BILLION CFU, boasting the pinnacle of probiotic excellence. This high-potency formula doesn't just aid digestion; it orchestrates a symphony of support for your immune system, leaving you feeling not just good, but fantastic.
- MOOD ISSUES? IT'S IN YOUR GUT!: Uncover the profound connection between your gut health and mood. Our Mood Probiotic is a carefully formulated solution that addresses both aspects, leveraging powerful bacterial strains and prebiotic GOS in harmony for a holistic approach to well-being.
If you need that extra boost in the morning or experience stomach issues on a regular basis, then we’ve got exactly what you need! Lifted Naturals Probiotics is a high potency probiotic supplement that can help with both mood and digestion.
Pros | Cons |
Contains 30 billion CFU with the best probiotic strains for mood and digestion. Features targeted “feel good” strains for improved mood and overall well-being. Shelf-stable formulation, which means no refrigeration is required, making it convenient for travel. | Some users may experience mild digestive discomfort when first starting to take the supplement. Only available in capsule form, which may not be ideal for those who have difficulty swallowing pills. May take a few weeks to see noticeable improvements. |
Lifted Naturals Probiotics contains nine nourishing strains, including B. Infantis and B. Longum, to ensure healthy digestion, immunity, and mood support. It features a “feel good” strain for a more positive outlook in life. The product is vegan, non-GMO, and comes in a 60-capsule bottle, providing a two-month supply. Additionally, it has a shelf-stable formulation, meaning refrigeration is not required, making it convenient for travel.
However, this supplement is only available in capsule form, which may not be ideal for those having difficulty in swallowing pills. Some users have also reported experiencing mild digestive discomfort when they first started taking the supplement. It may also take a few weeks to see noticeable improvements.
Jo’s Mood Daily
- 17 Science-backed Ingredients: Mood Daily was formulated by 20+ scientists & doctors using peer-reviewed research to hand-pick ingredients & dosages that synergistically work to support optimal mood.
- Boost Mood & Brain Power: Nootropic herbs & adaptogens like Bacopa Monnieri, Ashwagandha and Rhodiola Rosea can provide stress and worry relief while boosting focus.
- All-in-one Mood & Brain Supplement: 17 ingredients working together to support serotonin, GABA, Norepinephrine, dopamine, & BDNF levels while also supporting cognitive function and adrenal function.
Are you looking for an all-in-one mood and brain supplement? If so, then Jo’s Mood Daily might be the perfect choice for you!
Pros | Cons |
Features 17 science-backed ingredients that work together to support optimal mood and brain health. Does not contain necessary ingredients to ensure its effectiveness and efficiency. Non-drowsy, plant-based supplement that is gluten-free, vegan, non-GMO, and CGMP-certified. | Necessary to consult with a physician before taking this supplement, especially if you are taking medication or have a medical condition. May impair your ability to operate heavy machinery, therefore be cautious before taking it. Not intended to diagnose, treat, cure, or prevent any disease. |
Jo’s Mood Daily is an excellent choice for those looking for a supplement that targets all the body’s mechanisms that affect mood and brain health. With 17 science-backed ingredients, this supplement is formulated to support serotonin, GABA, Norepinephrine, dopamine, and BDNF levels while also supporting cognitive function and adrenal function
It also offers nootropic herbs and adaptogens such as Bacopa Monnieri, Ashwagandha, and Rhodiola Rosea for stress relief while boosting focus. Every ingredient in this supplement has a purpose and is in its most bioavailable form, making it easy for the body to absorb effectively.
However, if you are taking medication or have a medical condition, it’s necessary to consult with a physician before taking this supplement. This supplement is not intended to diagnose, treat, cure, or prevent any disease, although it can be used as a complementary option. It’s also important to take note that this supplement may impair your ability to operate heavy machinery, therefore be cautious before taking it.
Other Ways to Increase Dopamine Levels

Having a dopamine deficiency can produce negative effects all throughout the body. In order to fix low levels of dopamine, consider these alternatives:
Exercise
Working up a sweat by walking, running, dancing, swimming or any other forms of movement can increase dopamine levels. A study on animals has shown that certain portions of the body have been flushed with dopamine during physical activities.
Music
While it’s not 100% certain how music can affect the brain, there have been various studies where certain songs have shown to give you chills, make you mellow, and notably have the power to invigorate you while listening. This gives music the potential to stimulate production in the brain, leaving a person with feelings of pleasure and excitement.
Diet Changes
Changing one’s diet may affect dopamine. While eating a high fat diet can activate the dopamine system, over time this type of diet may lower dopamine signaling. However, early animal studies suggested that unsaturated fat may not have the same effect. Consuming foods containing the amino acid l-tyrosine may help the body make more dopamine. Some of these foods include beef, chicken, eggs, beans, dairy, plantains, peas, eggplants, tomatoes, and citrus fruits.
Probiotics
Probiotics do not receive the attention they truly deserve for promoting gut health, but this bacteria is not only an important part of the body’s microbiome. According to a study by Peuhkuri et al. (2011), probiotics may also be useful for the production of dopamine and other neurotransmitters.
With these suggestions in mind, the body’s dopamine levels can greatly increase. Be sure to give them a try and see what works best for you and your body’s needs.
FAQs
What are the side effects of taking dopamine supplements?
Dopamine supplements are generally safe when taken at appropriate doses. However, an excessive intake may cause side effects such as headaches, nausea, and insomnia. It is important to consult with your healthcare professional before taking dopamine supplements, especially if you have any pre-existing medical conditions.
Can serotonin and dopamine supplements be taken simultaneously without adverse effects?
Serotonin and dopamine supplements can be taken together, although it is best to speak with a healthcare professional for additional advice. Otherwise, it may lead to adverse effects such as serotonin syndrome, which can be life-threatening.
How effective are dopamine supplements in enhancing mood?
Dopamine supplements have shown positive results in enhancing mood, however its effectiveness may vary per person.
What role does L-theanine play in the regulation of dopamine?
L-theanine is an amino acid that is found in tea leaves and is known to reduce stress and promote relaxation. Its use has shown to increase dopamine levels in the brain, which can improve mood and cognitive function.
How does tyrosine contribute to dopamine production?
Tyrosine is an amino acid that is a precursor to dopamine production. It is converted into L-DOPA, which is then converted into dopamine. Consuming foods rich in tyrosine, or taking tyrosine supplements, can help increase dopamine levels in the brain.
Disclaimer: Last update on 2025-02-14 / Affiliate links / Images from Amazon Product Advertising API.
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